• Skip to primary navigation
  • Skip to main content
College of Agriculture & Life Sciences
  • About
    • Home Page: Welcome to Food Science & Technology
    • Overview: About
    • Strategic Plan
    • External Advisory Board
  • Academics
    • Undergraduate Programs
      • Undergraduate Brochure
      • Undergraduate Programs
      • Undergraduate Academic Advisors
      • FSTC Force List
    • Graduate Programs
      • Graduate Brochure
      • Graduate Programs
      • Graduate Program Application
      • Graduate Advising
  • Research
    • Research Overview
    • Faculty Research
    • Facilities
    • Areas of Excellence
    • Food Diversity Innovation Program
      • FDIP Home
      • IFANCA Endowment
      • Food Diversity Certificate
      • IFANCA Fellowships and Scholarships
      • IFANCA-FDIP Symposium on Nov.17, 2022
      • FDIP Inaugural Symposium
  • Resources
    • Current Student Resources
    • Future Student Resources
    • Links
  • Directory
    • Faculty
    • Graduate Students
    • Staff Directory
  • News
    • FSTC News
    • FSTC E-newsletter
      • FSTC e-newsletter- September 2023
      • FSTC e-newsletter-May 2023
      • FSTC e-newsletter- Dec 2022
    • FSTC LinkedIn
    • Scholarships
      • FSTC Scholarships
      • 2023 Scholarship Recipients
      • 2022 Scholarship Recipients
      • 2021 Scholarship Recipients
  • Opportunities
    • Student Opportunities
      • FSTC Internal Scholarships
      • External Scholarships
        • TFPA Scholarship Application
        • TFPA Scholarship Cover letter
        • Alamo IFT Scholarship Application
        • IFMA Scholarship Application
      • ENRICH- Research Opportunities for Undergraduates
      • CareersInFood.com
  • Food Science Club
  • Giving
  • Contact
Search

← All People

No photo found

Shaodong Guo

Associate Professor
Office:
123A Cater-Mattil
Email:
Shaodong.guo@tamu.edu
Phone:
979-845-0850
http://nfscfaculty.tamu.edu/guo/
Undergraduate Education
Huazhong Agricultural University, 1989
B.S. in Agronomy
Graduate Education
Peking University, 1995
Ph.D. in Physiology
Awards
2015- American Diabetes Association Research Excellent Thomas R Lee Award
2015- American Diabetes Association Career Development Award
2007- American Diabetes Association Junior Faculty Award
1999- Travel Award of American 81st Annual Meeting of Endocrine Society
1999- Young Investigator Award, National Natural Science Foundation of China
1999- Young Investigator Award, Institute of Genetics and Developmental Biology of Chinese Academy of Sciences, Beijing, China
1995- Guanghua Scholarship for outstanding Ph.D. Student Award, Peking University, Beijing, China
Courses Taught
NUTR 481: Nutrition Seminar
MSCI 612: Current Topics in Cell Signaling
MSCI 601: Cell Biology
MPHY 631: Cardiovascular Science
MPHY 632: Cardiovascular Pathology

Research Interest

The long-term goal of our research is to study the molecular mechanisms of insulin signal transduction, insulin resistance and associated cardiovascular dysfunction, aiming at nutritional and therapeutic intervention for control of metabolic and cardiovascular disorders. My laboratory is focused on the study of cellular signaling and gene transcriptional regulation of metabolic homeostasis that are governed by the PI3K→Akt→FoxO pathway, with the hope of understanding how dysregulation of this pathway in insulin/IGF-1 action causes liver damage, cardiovascular dysfunction, and pancreatic beta cell failure, resulting in diabetes, obesity, and organ failure. Our research encompasses several areas. Firstly, we will decode the mechanism of insulin resistance and associated cardiovascular dysfunction. It is known that excess nutrients cause or accelerate insulin resistance, investigating how nutrient-mediated signaling activates intracellular mediators that attenuate the insulin→IRS→Akt→FoxO signaling pathway will provide a powerful platform for nutritional and therapeutic intervention for the treatment of diabetes and cardiovascular disorders. The discovery of bioactive compounds, functional food, peptides, nucleotides, or stem cells that increase gene expression of IRS or promote FoxO phosphorylation and ubiquitination will promote drug development and provide new insights on nutritional and therapeutic targets. Secondly, we will define the roles of FoxO proteins in insulin signaling and insulin resistance through creation of cell lines and animal models in which FoxO is either eliminated by a genetic “knock-out” or increased by overexpression. This will also include studies utilizing the technique of tissue specific gene inactivation or activation (knock-in) to determine the role of FoxO in various tissues, including classic and non-classic target tissues for insulin action, such as liver and heart. Lastly, we will explore the novel players mediating insulin actions, as well as other hormones including glucagon, in control of energy metabolism and survival. We have taken advantage of IRS and FoxO genetically engineered mouse and cell models with analyses in genomics, proteomics, and metabolomics, to better define the physiological connections between metabolic regulation and FoxO in intracellular signaling networks.

Publications

[pmid-refs key=”guo” limit=3]

A member of
Texas A&M AgriLife

Texas A&M AgriLife Extension Service | Texas A&M AgriLife Research | Texas A&M Forest Service | Texas A&M AgriLife Veterinary Medical Diagnostic Lab | College of Agriculture & Life Sciences

More Information

  • Undergraduate Programs
  • Contact Us
  • Research
B130 Centeq | 2256 TAMU
1500 Research Pkwy, College Station, TX 77843
979-845-1735 LinkedIn

© 2023 Texas A&M University. All rights reserved.

  • Compact with Texans
  • Privacy and Security
  • Accessibility Policy
  • State Link Policy
  • Statewide Search
  • Veterans Benefits
  • Military Families
  • Risk, Fraud & Misconduct Hotline
  • Texas Homeland Security
  • Texas Veterans Portal
  • Equal Opportunity
  • Open Records/Public Information